N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine
UNC 0631
CAS: 1320288-19-4
Molecular Formula: C37H61N7O2
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Names and Identifiers
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Physico-chemical Properties
| Molecular Formula | C37H61N7O2 |
| Molar Mass | 635.93 |
| Density | 1.114±0.06 g/cm3(Predicted) |
| Boling Point | 763.4±70.0 °C(Predicted) |
| Solubility | Soluble in DMSO, not in water |
| pKa | 9.34±0.70(Predicted) |
| Storage Condition | 2-8 ℃, dark |
| Use | UNC-0631 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53. |
| Target | G9a |
| In vitro study | UNC 0631 (Compound 7) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC 0631 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC 0631 reduces H3K9me2 levels with ICW IC 50 values of 25 nM, 18 nM, 26 nM, 24 nM, 51 nM, 72 nM and 46 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively. |
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Reference
| Reference Show more | 1: Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50. doi: 10.1021/jm200903z. Epub 2011 Aug 5. PubMed PMID: 21780790; PubMed Central PMCID: PMC3171737. |
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.573 ml | 7.863 ml | 15.725 ml |
| 5 mM | 0.315 ml | 1.573 ml | 3.145 ml |
| 10 mM | 0.157 ml | 0.786 ml | 1.573 ml |
| 5 mM | 0.031 ml | 0.157 ml | 0.315 ml |
Last Update：2024-01-02 23:10:35
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Cell Experiment
MDA-MB-231, PC3, HCT116 cells are cultured in RPMI with 10% FBS, 22RV1 cells in alphaMEM and 10% FBS, MCF7 and IMR90 cells in DMEM with 10% FBS. Cells are treated with inhibitors for 48 h. The media is removed and replaced with DMEM 10% FBS without phenol red supplemented with 1mg/mL of MTT and incubated for 1–2 h. Live cells reduce yellow MTT to purple formazan. The resulting formazanis solubilized in acidified isopropanol and 1% Triton. Formazan signal absorbance is measured at 570 nm and corrected for the 650 nm background. IC50s are calculated using GraphPad Prizm statistical package with sigmoidal variable slope dose response curve fit.(Only for Reference) Cell lines: MDA-MB-231, PC3, HCT116, 22RV1, MCF7 and IMR90 cells
Last Update：2023-08-16 21:32:38
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine - Introduction
UNC 0631 is an organic compound, belonging to a bisaminomethylproline Ester compound. It is synthesized by the reaction of fatty methacrylate and bisaminomethylproline. The UNC 0631 has a white or light yellow solid. It is a compound that is soluble in organic solvents such as dimethyl sulfoxide.
UNC 0631 is used as a chemical research reagent to study cell signaling and molecular mechanisms. It has important application value in studying the function and regulation of G protein coupled receptors and other related proteins.
The method for preparing UNC 0631 is to mix fatty methacrylate and bisaminomethylproline in a certain proportion and react under appropriate conditions. The specific preparation method can be obtained by literature or patent.
When using UNC 0631, you need to pay attention to the following security information:
1. When operating UNC 0631, you need to wear laboratory safety equipment, such as gloves, glasses and laboratory coats, to avoid contact with skin and eyes.
2. Avoid inhaling the vapor of powder or solution to avoid respiratory irritation.
3. UNC 0631 may be potentially harmful to the environment. Follow the correct disposal method and do not discharge it into water sources or the environment.
4. When using UNC 0631, keep the room well ventilated and follow the regulations on storage and handling of dangerous goods.
UNC 0631 is used as a chemical research reagent to study cell signaling and molecular mechanisms. It has important application value in studying the function and regulation of G protein coupled receptors and other related proteins.
The method for preparing UNC 0631 is to mix fatty methacrylate and bisaminomethylproline in a certain proportion and react under appropriate conditions. The specific preparation method can be obtained by literature or patent.
When using UNC 0631, you need to pay attention to the following security information:
1. When operating UNC 0631, you need to wear laboratory safety equipment, such as gloves, glasses and laboratory coats, to avoid contact with skin and eyes.
2. Avoid inhaling the vapor of powder or solution to avoid respiratory irritation.
3. UNC 0631 may be potentially harmful to the environment. Follow the correct disposal method and do not discharge it into water sources or the environment.
4. When using UNC 0631, keep the room well ventilated and follow the regulations on storage and handling of dangerous goods.
Last Update：2024-04-09 19:05:02
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Product Name: UNC 0631 Visit Supplier Webpage Request for quotation
CAS: 1320288-19-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1320288-19-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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